ABCD Child Functional Brain Network Assignments
This folder contains group average Infomap-derived function network assignments from 2 cohorts of ~1,000 individuals (9 & 10 yr olds) in the ABCD dataset.
Please cite: Marek S, Tervo-Clemmens B, Nielsen AN, Wheelock MD, Miller RL, Laumann TO, Earl E, Foran WW, Cordova M, Doyle O, Perrone A, Miranda-Dominguez O, Feczko E, Sturgeon D, Graham A, Hermosillo R, Snider K, Galassi A, Nagel BJ, Ewing SWF, Eggebrecht AT, Garavan H, Dale AM, Greene DJ, Barch DM, Fair DA, Luna B, Dosenbach NUF. (2019). Identifying Reproducible Individual Differences in Childhood Functional Brain Networks: An ABCD Study. Developmental Cognitive Neuroscience, in press.
Midnight Scan Club
The Midnight Scan Club (MSC) data set contains 10x high-fidelity individual connectomes (24-34 yo; 5F). For each participant 5 hr of RSFC data, 6 hr of task fMRI data, 4x T1, 4x T2, 4x MRA, 4x MRV and neuropsychological assessments including the NIH toolbox are available. All MRI data were collected after midnight to control for time of day effects. The data are freely available in raw format from openfmri.org and in processed format from neurovault.org.
Please cite: Gordon EM, Laumann TO, Gilmore AW, Newbold DJ, Greene DJ, Berg JJ, Ortega M, Hoyt Drazen C, Gratton C, Sun H, Hampton JM, Coalson RS, Nguyen A, McDermott KB, Shimony JS, Snyder AZ, Schlaggar BL, Petersen SE, Nelson SM, Dosenbach NUF. Precision functional mapping of individual human brains. Neuron. 2017;95(4):791-807.
Motion Feedback
A major limitation to structural and functional MRI (fMRI) scans is their susceptibility to head motion artifacts. Even submillimeter movements can systematically distort functional connectivity, morphometric, and diffusion imaging results. In patient care, sedation is often used to minimize head motion, but it incurs increased costs and risks. In research settings, sedation is typically not an ethical option. Therefore, safe methods that reduce head motion are critical for improving MRI quality, especially in high movement individuals such as children and neuropsychiatric patients. We investigated the effects of (1) viewing movies and (2) receiving real-time visual feedback about head movement in 24 children (5-15 years old). Children completed fMRI scans during which they viewed a fixation cross (i.e., rest) or a cartoon movie clip, and during some of the scans they also received real-time visual feedback about head motion. Head motion was significantly reduced during movie watching compared to rest and when receiving feedback compared to receiving no feedback. However, these results depended largely on age, such that the effects were driven by the younger children. Children older than 10 years showed no significant benefit. We also found that viewing movies significantly altered the functional connectivity of fMRI data, suggesting that fMRI scans during movies cannot be equated to standard resting-state fMRI scans.
The implications of these results are twofold:
(1) given the reduction in head motion with behavioral interventions, these methods should be tried first for all clinical and structural MRIs in lieu of sedation.
(2) For fMRI research scans, these methods can reduce head motion in certain groups, but investigators must keep in mind the effects on functional MRI data.
Please cite: Greene DJ, Koller JM, Hampton JM, Wesewich V, Van AN, Nguyen AL, Hoyt C, McIntyre L, Earl EA, Klein RA, Shimony JS, Petersen SE, Schlaggar BL, Fair DA, Dosenbach NUF. Behavioral interventions for reducing head motion during MRI scans in children. Neuroimage. 2018; Jan 11.
Motion Feedback Videos
These custom video clips were used to present to child participants during resting-state scans in our study investigating movie clips and feedback on head motion. The clips consist of cartoon blockbuster movies edited for our specific research purposes. Three movies were used to make a total of seven movie clips that were shown to participants in a randomized order. Two clips were taken from Big Hero 6 (Disney Movies), two were from Despicable Me (Illumination Entertainment, Universal Pictures), and three were from Finding Nemo (Disney Movies, Pixar). Clips were chosen on the basis of being engaging, but not overly exciting or upsetting. Clips are approximately 7 minutes each corresponding to the length of the scans. We found that viewing movies significantly altered the functional connectivity of fMRI data, suggesting that fMRI scans during movies cannot be equated to standard resting-state fMRI scans. However, movie watching can reduce head motion in certain groups and should be used in clinical and structural MRIs without issue. For fMRI scans, investigators must keep in mind the effects on the data.
Please cite: Greene DJ, Koller JM, Hampton JM, Wesewich V, Van AN, Nguyen AL, Hoyt C, McIntyre L, Earl EA, Klein RA, Shimony JS, Petersen SE, Schlaggar BL, Fair DA, Dosenbach NUF. Behavioral interventions for reducing head motion during MRI scans in children. Neuroimage. 2018; Jan 11.
PEdiatric ACcelerometry (PEAC) Dataset
Our referent pediatric accelerometry (PEAC) data set represents more than 14 000 hours (561 days) from 156 children aged 0 to 17 years and provides a critical foundation for future studies to describe activity across childhood.
Please cite: Catherine R. Hoyt, Andrew N. Van, Mario Ortega, Jonathan M. Koller, Elyse A. Everett, Annie L. Nguyen, Catherine E. Lang, Bradley L. Schlaggar, Nico U. F. Dosenbach. Detection of Pediatric Upper Extremity Motor Activity and Deficits With Accelerometry. JAMA Network Open. 2019; 2(4): e192970.